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KMID : 0371619950110010083
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Journal of Wonkwang Medical Science
1995 Volume.11 No. 1 p.83 ~ p.94
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A Diagnostic Significance of the Alcian blue, Cytokeratin, AgNOR and PCNA stain on the Papillary Structures of the Thyroid.
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Abstract
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The papillary structures are occasionally found in the adenomatous goiter, follicular adenoma of the thyroid gland and papillary thyroid carcinoma. These papillary lesions are difficult to differentiate between benign and malignant thyroid
diseases
by
the hematoxylin-eosin stain.
This study was aimed to differentiate between benign and malignant papillary structures in the thyroid diseases by the PAS, alcian blue(pH2.5), cytokeratin, nuclear organizer region(AaNOR) and proliferating cell nuclear antigen(PCNA) stains. The
tissue
sections were taken from 10 cases of papillary lesions in the benign thyroid disease(8 cases of hyperplastic goiter and 2 cases of follicular adenoma) and 13 cases of papillary thyroid carcinoma.
@ES The results were as follows.
@EN 1. The neutral mucin by the PAS stain was present in the 1 cases of 10 benign papillary lesions(10.0%) and 2 cases of 13 malignant papillary lesions(15.4%).
2. The acid mucin was not stained in the stroma of the all benign papillary lesions, and moderately or strongly stained in the 6 cases of 13 malignant papillary lesions(46.2%) by the alcian blue stain(pH2.5).
3. The cytokeratin was weakly positive in the benign papillary lesions and positive in the 7 cases of 13 malignant papillary lesions(53.8%).
4. The mean number of AgNOR was 1.24±0.31 in the benign papillary lesions and was 1.33±0.05 in the malignant papillary lesions.
5. The percentage of the PCNA positive cells was 1.0±0.4% in the benign papillary lesions and was 12.1±3.0 in the malignant papillary lesions.
Above result indicate that the alcian blue(pH2.5), cytokeratin and PCNA stains were helpful methods for differential diagnosis between benign and malignant papillary lesions in the thyroid diseases.
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KEYWORD
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